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The ability of auranofin-loaded chitosan-lipid hybrid nanoparticles (AUF-CLHNPs) to modulate GSK-3/Nrf2/HO-1 signaling pathways in a rotenone-induced PD model was studied and it was found that AUF-CLHNPs significantly improved auranofins brain penetration, overcoming its limited natural bioavailability

Down-regulating TXNRD3 may help explain COVID-19-associated orchitis (Reference Xu, Qi and Chi75) or gastrointestinal manifestations since suppression of TXNRD3 promotes colitis (Reference Liu, Du and Zhu76)