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Wei Zheng, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Factors such as heterogeneous clinical manifestations, geographic dispersion, limited patient numbers and high disability rates exacerbate these challenges

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Analysis was performed with the R program [56]

We conclude that the tandem Y-motifs are critical for Wnt-dependent signaling of LRP6 in a complementation assay based on LRP5/6 DKO cells