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a suitable vector contains an origin of replication functional in at least one organism, a promoter sequence, convenient restriction endonuclease sites, and one or more selectable markers see, e.g., WO 01/96584

Accordingly, skin elasticity was shown to be improved by 13% after supplementation, compared to an increase of 1% in the placebo group

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Toxicol Appl Pharmacol 272:787796 Jin H, Joung S, Park J, Baek HS, Park TS (2007) The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy