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Arasaradnam, R

BACH1 and Immune Cell Differentiation BACH serves as a crucial regulatory factor for innate and adaptive immune systems, such as influencing the differentiation of B and T cell lineages, CD4 + regulatory T cells, and macrophages

Abstract DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (cancer and repetitive sequences-associated diseases) are regulated

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Regarding patients fibroblasts, at the early-stage ATP is produced mainly through mitochondrial respiration, while at the late-stage ATP production relies more on glycolysis (Fig