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2 Table 2 Clinical Manifestations of Vitamin B12 Deficiency Maternal vitamin B 12 deficiency during pregnancy or while breastfeeding may lead to neural tube defects, developmental delay, failure to thrive, hypotonia, ataxia, and anemia

This classification considers both extremes of vitamin B 12 diagnostics, i.e., very low and very high vitamin B 12 status

Patients often become frustrated by the lack of improvement and want something to alleviate the pain and disability

Various biophysical techniques suitable for the analysis of the dynamic structures of IDPs/IDRs have been thoroughly explained in comprehensive reviews and books (Daughdrill et al., 2005