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Since hormones and growth factors, including IGF-1, function to promote growth by inducing cell proliferation and survival, hormone antagonists are often investigated as means for treating abnormal cell growth such as carcinogenesis

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Compared to humans and mice, rats have a higher basal level of antioxidant defense gene expression, and rats have a greater capacity to respond to cellular stress, which makes them generally more resistant to drug toxicity [127]

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Of note, the ratio of fused/fragmented mitochondria in the high glucose condition very much resembled that of BIM-deficient cells (Fig