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Tirzepatide is a novel medication that has shown great promise in the treatment of diabetes

ACKNOWLEDGEMENT The authors declare no conflict of interest relevant to this article

Here, we focus on the underlying mechanism of IR including direct defective of insulin signaling, epidemiological factors, interorgan metabolic crosstalk, metabolic mediators, genetic mutation, epigenetic dysregulation, non-coding RNAs, and gut microbiota dysbiosis

Reductive substrates were enriched in the AC-like murine model compared to the NPC-like model, with significantly increased NADH/NAD ratio and marginally elevated NADPH/NADP and CoQH2/CoQ4 or CoQH2/CoQ9 ratios (Fig

Cell Metabolism , 26 , 801 Liu, B., Page, A