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In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

ADCC: antibody-dependent cellular cytotoxicity

The right form depends on the patients health needs and therapy type

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5 Safety Profile : Because it acts directly on adipose tissue, AOD 9604 may have a lower risk profile compared to other interventions based on HGH that affect multiple systems in the body