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While anti-viral therapy can slow down the progression of liver fibrosis/cirrhosis, its effectiveness is limited in preventing cirrhosis from advancing to HCC ( P

Collectively, the in vitro results confirmed that iron overload caused the aberrant miRNA components in exosomes, which then interfered with mouse oocyte maturation by affecting the cell cycle, oocyte meiosis, and ferroptosis signaling pathway, while deferoxamine mesylate and VITE can effectively improve this situation

In vitro and preclinical studies indicate that cagrilintide retains high potency across amylin and calcitonin receptor subtypes and demonstrates additive pharmacodynamic effects when combined with GLP-1 agonists like semaglutide (DAscanio et al

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In addition, we observed that the number of activated microglia/macrophages at the injury site in the CD38-deficient mice was significantly lower than that in the WT mice, while CD38 was expressed in brain microglia