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Description

These effects lead to hippocampus-dependent cognitive loss, including difficulties with spatial learning and memory, as well as neurodegeneration, inflammation, and synaptic malfunction

Preclinical euglycaemic clamp data showed no impairment of insulin sensitivity at therapeutic doses

Zhi et al., 2018)

IFN- acts on the IFN- receptor, resulting in the phosphorylation of JAK1/2, which triggers the phosphorylation of STAT1 and leads to an increase in interferon regulatory factor 1 (IRF1) expression, which inhibits the function of SLC7A11 with SLC3A2 (system Xc ), ultimately leading to ferroptosis (61)