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Treatment randomization and blinding Eligible patients were randomly assigned to the AST or placebo groups (1:1) using the balanced block randomization method within a block size of 4 by an independent statistician

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The best analogues (i.e., compounds 64, 69, and 72) were confirmed to possess anti-DENV activity in infected cells, showing low-micromolar antiviral potency, which was comparable with that of hit 3

Next-generation HK2/LDHA inhibitors with BBB penetrance and cell-specific targeting (preferential astrocyte vs