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For example, neuroinflammation causes the induction of a neurotoxic reactive subtype, termed A1-type astrocytes, by microglial cytokine release (Liddelow et al., 2017), which can kill oligodendrocytes and neurons by secreting toxic lipids

The use of SFN reported improvement in irritability, stereotypic/repetitive behavior, social cognition/interaction, social communication, hyperactivity and lethargy

Interestingly, various reports, including a study aimed at developing new insulin analogues thermally more stable and with more physiological profiles than human insulin provided evidence for the possibility to develop IR-A/IGF-1R targeting agents with higher specificity (66)