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At 1 year, the adverse reactions reported to be drug-related were impotence (erectile dysfunction), decreased libido, decreased ejaculate volume, ejaculation dysfunction, breast enlargement, breast tenderness (mastalgia), and rash (unspecified)

(B) In Dubin-Johnson syndrome (DJS), loss-of-function mutations in ABCC2 cause defective MRP2, preventing canalicular excretion of conjugated bilirubin

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Simultaneously, plasma 8-isoprostane, a specific biomarker indicating severe lipid peroxidation and damage to cell membranes, decreased by a massive 35%

A rise (inhale) and fall (exhale) of the chest count as one full breath or respiration