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Unscheduled DNA synthesis, induced by the N -acetoxy-2-acetylamino- fluorene, was inhibited by ethylene oxide in human lymphocytes in vitro (Pero et al., 1981)

However, research into this kind of supplementation remains lacking

Axon degeneration Several studies in humans and animals have demonstrated axon degeneration after long-term administration of chemotherapeutic agents, including the loss of large myelinated, small unmyelinated (more rarely), and intra-epidermal nerve fibers (IENF) which may be connected to the development of sensory-motoric peripheral neuropathy (Bradley et al., 1970

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After rinsed with PBS, the cells were exposed to 400 M H 2 O 2 for 4 h