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Some clinical studies have shown that pioglitazone treatment (30 mg/day, P.O for 4 weeks) exhibits antioxidant properties in diabetic patients, as reflected by a decrease in MDA [218, 219]

Although a more recent ICOP 2020 taxonomy existsand a recent systematic review found no material clinical or epidemiologic differences versus ICHD-IIIwe based enrollment on ICHD-III to preserve continuity and comparability 23,24

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