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Chronic skin inflammation in AD patients is caused by persistent Th2 inflammation and skin barrier disruption, accompanied by significant reactive oxygen species (ROS) production (17)

This pattern mirrors the consequences of HHEX deficiency, where HHEX KO inhibits efficient pancreatic fate acquisition and promotes hepatic marker expression in hPSC-derived endoderm 7

This data suggests that tazarotene can be an effective option for addressing hyperpigmentation in individuals with certain skin conditions, such as acne, particularly in black patients 3