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Valsartan had no adverse effects on the reproductive performance of male or female rats at oral doses of up to 200 mg/kg/day

In addition, numerous enzymes that involved in thiopurine biotransformation and their variable activities offer a clue for the measurement of serum metabolites which reflect the drug metabolism and distribution and facilitate the determination of the optimum dose of medications for each patient to prevent side effects and toxicities [130] (Fig

Given the complexity of the female reproductive system, it is essential to thoroughly investigate the effects of natural products on maternal metabolic processes before clinical use

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Drug Targets 11 , 599613 (2010)