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10.1016/j.lfs.2020.117918 48 LiuY.LiuW.ZhangZ.HuY.ZhangX.SunY.et al (2021b)

Prostate 71 , 11391150 (2011)

TCM also mitigates subjective symptoms (fatigue, edema) unaddressed by conventional therapies and poses lower risks of hypotension/electrolyte disorders, even in advanced CKD ( 4.2 Nutrient-sensing mechanisms: Key players in DKD pathogenesis While malnutrition is indeed a secondary manifestation of metabolic and renal dysfunction, nutrient sensing dysregulation (e.g., via AMPK/SIRT1/mTORC1 pathways) constitutes a pivotal mechanism in DKD progression, deeply intertwined with oxidative stress and autophagy impairment