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Overall, existing clinical treatment methods primarily focus on symptom control and do not intervene in the fundamental pathological mechanisms of disc degeneration

Here, cuprizone-induced intoxication has gained a lot of attention and acceptance in recent years (Matsushima and Morell, 2001

doi:10.1007/s00253-017-8616-7

It prompted that the differences in locomotor behavior were not due to novelty since the novelty-induced hyperactivity is usually observed within the first 510 min and dramatically normalize afterwards