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On the other hand, Fe 2 in the labile iron pool is redox-active and can act as a catalyst in the Fenton reaction [18, 19], reacting with hydrogen peroxide to produce highly reactive hydroxyl radicals, which can inflict oxidative damage on cellular components, including DNA, proteins, and cell membranes lipids, lead to the accumulation of lipid reactive oxygen species (ROS)

Veldhuis JD, Keenan DM, Bailey JN, et al

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Published literature may describe its activity in cell-based and animal-model research, but those references are provided only for scientific context

Inhibiting the function of ABC transporters using small molecules is considered a potential strategy for reversing MDR (Palmeira et al., 2012