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So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations

[DOI] [PMC free article] [PubMed] [Google Scholar] Wermuth B, Mnch JD, von Wartburg JP

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One drawback of these methods is that most of them employ the meticulously controlled autoclave