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Dominant-negative mutations in collagen I, III, and V cause several different forms of EDS (Figure 1)

In some places, bacteriostatic water is available over the counter, while in other countries, youll need a prescription

Maximum peripheral IV concentration should not exceed 40 milliequivalents per liter, with infusion rates no faster than 10 milliequivalents per hour through a peripheral vein

Temporary pain Infection at the injection site Temporary leg weakness Possible sciatic nerve block Dizziness during or soon after the injection Nerve injury (rare) Allergic reactions to the medications used Increased fluid retention *** For diabetic patients: The use of a steroid (an anti-inflammatory) can cause an increase in blood sugar levels up to two weeks after the procedure

Conversely, a low Km means that only a small amount of substrate is needed to maximize the activity of the enzyme (high affinity)