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Description

Furthermore, PCBs have been shown to accelerate atherosclerosis through activation of the aryl hydrocarbon receptor (AHR), upregulation of adhesion molecules, production of ROS, endothelial dysfunction, and apoptosis in vascular cells [53]

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This review describes the enzymes involved in drug activation in the order they participate along the mercapturic acid pathway, GST, GT, and -lyase

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Ultimately, terminal membrane rupture releases DAMPs (High Mobility Group Box 1, HMGB1, Lactate Dehydrogenase, LDH) and cytokines (Tumor Necrosis Factor, TNF, IFN-), while permanently impairing cross-presentation capability

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