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These results demonstrate that the GD and CTD of AAGAB must be physically connected to regulate AP2 assembly, further supporting our conclusion that AAGAB is a bona fide bi-handed assembly chaperone relying on the proximity effect to regulate substrate pairing

1 Introduction Acute respiratory distress syndrome (ARDS) is a severe, life-threatening inflammatory condition of the lungs commonly triggered by infections such as bacterial pneumonia, viral pathogens (e.g., influenza and SARS-CoV-2), and systemic sepsis ( The pathogenesis of ARDS involves an exaggerated immune response that damages alveolar structures, disrupts the alveolar-capillary barrier, and promotes excessive inflammation, vascular leakage, and oxygenation failure ( Regulated cell death pathways, such as apoptosis, pyroptosis, necroptosis, and ferroptosis, play pivotal roles in controlling inflammation and maintaining tissue integrity

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In: Alvarez-Suarez JM (ed) Bee productschemical and biological properties