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428,429 HSPs are induced in response to various CNS pathologies, including neurodegenerative diseases, ischemia, and epilepsy, where they play a neuroprotective role by preventing protein aggregation and misfolding

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Thus, strategies which target factors involved in LSEC dysregulation may improve hepatic recovery and prevent the progression of certain pathological conditions, including non-alcoholic steatohepatitis (NASH)