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People with slow COMT function may want to avoid supplementing with high doses of methyl donor supplements, such as methylB12 (methylcobalamin) or methylfolate

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Choosing clinically tested products ensures better results and reduces the risk of adverse effects

The in vivo efficacy may be monitored by established standard methods for the respective disease entities including, but not limited to white blood cell counts, differentials, Fluorescence Activated Cell Sorting, bone marrow aspiration