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TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

First, CFIm25 and PAP interact directly, and the acetylation of CBP in their interaction region inhibits their binding

94 BAT8006 is an additional anti-FR ADC incorporating topoisomerase 1 (TOP1) inhibitor payloads with a DAR of 8, which has also advanced beyond preclinical studies to a Phase 2 trial, BAT8006, which is underway in PROC, fallopian tube, or primary peritoneal cancers 95 (Figure 4)