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Soluble uric acid activates the NLRP3 inflammasome

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Targeting calcium signaling in cancer therapy

Not a medicine, food, cosmetic, or dietary supplement

Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification