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GLUT1 is the predominant carrier and its overexpression is associated with malignancy and poor prognosis in cancer [23, 24], where it can be controlled by miRNAs

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The activation of MMPs can also induce tight junction degradation, leading to BBB breakdown following cerebral ischemia-reperfusion injury (Anctil et al., 2005

Strikingly, simply increasing mitochondrial GSH levels by expressing mito-GSHf in SLC25A39/40 double knockout cells completely restored the reduced levels of mitochondrial translation machinery proteins, iron-sulfur containing proteins, and aconitase activity (Fig 4f,g)