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It is necessary to expand extensive chronic clinical trials to evaluate the long-term safety, efficacy, and optimal dosing of polyphenols, examine gene-diet and microbiota-polyphenol interactions to elucidate inter-individual variability, develop innovative delivery systems to improve bioavailability and facilitate clinical translation, and clarify potential drug interactions and safety in vulnerable populations

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Table 1: Patient Risk Factors Associated with B 12 Deficiency Bold represents factors associated with more rapid onset of clinical symptoms i.e., within 5 years