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Outside-in signalling occurs when LFA1 binds to its ligand ICAM1, causing phosphorylation of the SRC or spleen tyrosine kinase (SYK) family kinases LCK and -chain-associated protein kinase of 70 kDa (ZAP70), and this leads to the production of high-affinity LFA1

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To maximize absorption and efficacy, polyphenols should be consumed with healthy fats, such as those from olive oil or avocados, or in formulations that enhance bioavailability, such as curcumin with piperine

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