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In addition, improving the oral bioavailability and extending the plasma half-life of peptide drugs remain major hurdles

Pemmaraju N, Bhalla K, Daver N, Wilson N, Fiskus W, Ravandi F, Garcia-Manero G, Kadia T, DiNardo C, Jabbour E, Burger J, Short N, Alvarado Y, Jain N, Masarova L, Verstovsek S, Issa G, Qiao W, Khoury J, Pierce S, Miller D, Konopleva M, Kantarjian H, Borthakur G

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Zimmermann, H

In the case of the JNK inhibitor SP600125, which is only soluble in DMSO and requires early treatment, 70% of the protection against APAP toxicity was caused by DMSO and 30% by SP600125 [36]