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The development of PCSK9 monoclonal antibodies including evolocumab and alirocumab have been demonstrated to lower LDL-C levels as well as CVD risks (Schwartz et al., 2018)

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Its use for therapeutic purposes is not widely approved and remains under investigation in clinical studies

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Kuzmichev, A., Jenuwein, T., Tempst, P

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The primary development and approved use for MT-1 centers on its therapeutic photoprotective effects

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