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Solvent accessibility into the primary binding site is unhindered by the F319, which remains splayed open thereby retaining dDAT in an outward-open conformation (Fig

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Given that the blood-brain barrier (BBB) excludes many systemic therapies, local control approaches such as surgical resection are used for initial management, often in combination with radiotherapy [4]

provides consulting services, including statistical analysis and dietary supplement formulation, through Tinsley Consulting LLC but has no conflicts of interest related to the use of paraxanthine

Taken together, these findings suggest that serotonergic hypoactivity alone does not fully account for the complex pathophysiology of MDD