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Filippo TS, Holder WD Jr

Adaptive resistance to MAPK inhibition in colorectal cancer

Other possible causes of acanthosis nigricans include Addison's disease, pituitary gland disorders, growth hormone therapy, hypothyroidism, or the use of oral contraceptives

Cell Physiol Biochem 46:16501667

While this approach is appropriate for capturing early oxidative and micronutrient-related alterations associated with disease severity, it does not allow evaluation of temporal dynamics, recovery patterns, or causal relationships, which would require longitudinal follow-up