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There are specific conditions needed for an efficient ADCC or CDC, including enough number of antibodies attached to the target cell, a sufficient number of effector immune cells (such as natural killer [NK] cells, monocytes, and granulocytes), and the absence of ADCC suppressor cells (such as regulatory T cells [Tregs] and myeloid-derived suppressor cells [MDSCs]) in the tumor microenvironment

For species level estimations (described in 46 ) in the heatmap, most of the OTUs could not be resolved to the species level (100% identity and coverage on NCBIs nucleotide BLAST: using the 16S rRNA database), and are thus reported as the resultant genera from our 16S sequencing