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In this synthesis process, cysteine (Cys) is the limiting substrate and its cellular uptake as the oxidized form, cystine (Cyss), is mediated by the cystine/glutamate antiporter xCT (encoded by the SLC7A11 gene)

At the later time points, 3 and 6 h after APAP, both plasma miR-122 and ALT started to increase, while the fold change of miR-122 is larger than of ALT (Fig

However, the role of thioredoxins in the protection against oxidative stress in these subjects is not clear and warrants further study