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These core functions shift as the liver matures, necessitating increased network connectivity during periods B and C

Therefore, nanotherapeutics rely on effective NP cellular uptake and tissue or tumor permeability that both depend on various factors, such as the size, shape, and surface chemistry of the NPs, as well as the biological (micro)environment, the specific location, and the targeted tissue [340,341,342]

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Therefore, in the long term, molecular manipulation of receptors, signal transduction molecules, ion channels, or smooth muscle growth may be fruitful tactics to enhance erectile function