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5-reductase-2 subjects both adults and children also have abnormal ratios of 5- to 5-reduced glucocorticoid and other steroid metabolites, indicating that this condition is a generalized defect in hepatic steroid 5-metabolism, clearly distinguishing them from androgen-insensitive subjects who may also have abnormal T/DHT ratios (18)

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Additionally, in the context of relatively healthy cohorts like aged or overweight individuals, or even in obese cohorts, NAD + modulation by NR did not correspond to significant changes in mitochondrial homeostasis 314,316,321,335,336

This ensured that only animals with successful surgical outcomes and no confounding complications were included in the primary data analysis [1]