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Thirty-two participants completed Phase I, of whom 29 (90.6%) were classified as high-TMAO producers ( 5 mol/L and 50% increase from baseline to 24-h follow-up)

Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

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Cyanide is a poison, of course, but in the minuscule quantities found in Cyanocobalamin, this is of no consequence its perfectly safe to take

It has been supplied in non-commercial glass brownish bottle containing 10-gm yellow powder and was freshly dissolved in drinking water prior to administration