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Before-and-after results typically emerge gradually, reflecting ongoing processes such as collagen and elastin remodeling, improved resilience, and enhanced tissue function rather than immediate cosmetic alteration

No specific high-affinity receptor for DSIP has been identified, making it difficult to establish a clear pharmacological mechanism

Active B12, or holotranscobalamin, is increasingly seen as a promising first-line marker, because it measures only the fraction that cells can use

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