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Whilst oxidative stress is well described in neurodegenerative disorders including amyotrophic lateral sclerosis (ALS), other aspects of redox dysfunction and their contributions to pathophysiology are only just emerging

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In the current study, CBD augmented an increase in HIF-1 levels recorded 24 h after exposure to hypoxia, likely by chelating transition metal ions 22 that inhibit the enzyme responsible for HIF-1 degradation 46,47

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