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This function involves the key substances nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide, which generate water by allowing hydrogen atoms to detach as protons, pass along the electron transport chain (ETC), and ultimately combine with oxygen, finally resulting in the release of massive free energy and the conversion of adenosine diphosphate to ATP via inorganic phosphate (12)

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Mitochondrial dysfunction leads to a loss of energy production, fatty acid accumulation, excess reactive oxygen species(ROS) generation, membrane instability, and a shift to glucose metabolism [1,2]