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Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions

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In homozygous LDLR mutant mice, it was shown in vivo that AAV-CRISPR/Cas9-mediated gene editing to correct the LDLR mutation resulted in decreased atherosclerosis and macrophage infiltration compared with placebo, as well as significant reductions in serum total cholesterol, LDL-C, and TG