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Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation

The same free thiol (-SH) group that enables thiol exchange also allows NAC to act as a direct, localized antioxidant

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Recommended daily intake: Adults: 10-13mg per kg body weight per day For a 70kg (154lb) person: approximately 700-910mg methionine daily Athletes or those with higher needs: 15-20mg per kg body weight Sample daily meal plan to increase homocysteine: Breakfast: 2 eggs scrambled (380mg) 30g cheese (200mg) Total: ~580mg methionine Lunch: 150g chicken breast (1,400mg) Quinoa salad (95mg per 100g serving) Total: ~1,500mg methionine Snack: 30g Brazil nuts (300mg) Total: ~300mg methionine Dinner: 150g salmon (940mg) Roasted vegetables Total: ~940mg methionine Daily total: ~3,320mg methionine (well above minimum requirements) Vegan/vegetarian meal plan: Breakfast: Oatmeal with hemp seeds and Brazil nuts (500mg+) Fortified plant milk (varies) Lunch: Tofu stir-fry with quinoa (400mg+) Sesame seed garnish (100mg) Snack: Sunflower seed butter on whole grain bread (300mg) Dinner: Lentil and chickpea curry (200mg) Brown rice (60mg) Daily total: ~1,560mg methionine (adequate for most people, though lower than omnivorous diet) Important considerations: Balance is key: You want to raise homocysteine to optimal levels (6-9 mol/L), not create high homocysteine

10.3390/ijms21134777 Int J Mol Sci