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For instance, neuroinflammatory signaling can exacerbate oxidative stress, while mitochondrial failure impairs the energy-intensive processes underlying synaptic plasticity

On the one hand, tumor cells are metabolically dependent on methionine, and abnormal activation of its metabolic cycle is one of the hallmarks of HCC [91]

For example, platinum-based drugs are especially used for testicular cancer, which directly form DNA adducts and lead to intrastrand and interstrand cross-links [86]

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Signaling pathways can also promote microtubule stabilization by inhibiting the activity of proteins that destabilize microtubules