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[10] IGF-1 levels are correlated with insulin sensitivity, where lower levels of IGF-1 would appear to coincide with a decrease in in insulin sensitivity

doi: 10.1111/j.1600-0897.2010.00852.x 95 GlebezdinaNSNekrasovaIVOlinaAASadykovaGKKuklinaEM

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Mitochondrial dysfunction and oxidative stress play significant roles in neurodegenerative diseases, and both generate high levels of reactive oxygen species (ROS), which are harmful to all cellular macromolecules