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This oxidant stress causes activation of a MAP kinase cascade in the cytosol ultimately leading to phosphorylation of c-jun N-terminal kinase (P-JNK), translocation of P-JNK to the mitochondria [34], and binding to the anchor protein Sab [35] for amplification of the mitochondrial oxidant stress and peroxynitrite formation in the mitochondrial matrix [33, 36]

doi:10.1016/j.nbd.2013.10.017

doi: 10.1186/s12885-021-07785-w 64 TangSWYangTCLinWCChangWHWangCCLaiMKet al

For example, AZ is being challenged over patents for its asthma inhaler Symbicort (budesonide/formoterol), which made $2.5 billion in sales last year, with other letters highlighting Boehringers $1.6 billion chronic obstructive pulmonary disease (COPD) therapy Spiriva (tiotropium bromide) and Mylans EpiPen (epinephrine) products, which had $378 million in 2022 revenues and have come under scrutiny for big price rises in recent years

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