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At a glance Direct interaction / none documented between vitamin B12 and mixed amphetamine salts Safety rating / generally recognized as safe to combine at standard doses Dose separation / not required, though taking B12 with food may improve absorption Common B12 dose / 500 to 1,000 mcg oral daily for supplementation Adderall XR mechanism / CNS stimulant releasing norepinephrine and dopamine B12 mechanism / cofactor in myelin synthesis, DNA production, and homocysteine metabolism Monitoring / serum B12 and methylmalonic acid (MMA) if deficiency is suspected Prevalence of low B12 / approximately 6% of U.S