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The intervention was delivered as single weekly intravenous infusion, with each dose administered over 15 min in 50 mL of saline, for two consecutive 8-week periods, separated by a 1-week washout

PubMed Research indicates that retinoids including retinol remain the gold standard for topical anti-aging treatments, though their application is frequently limited by skin irritation and poor tolerability, particularly in sensitive or aged populations